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DIGOXIN LEVEL
Test CodeLAB23
CPT Codes
80162
Preferred Specimen
One 6 mL red top tube
Pediatric: One red top microtainer
Pediatric: One red top microtainer
Other Acceptable Specimens
Dark Green
Instructions
Sample must be centrifuged within two hours of collection. Serum/plasma must be removed from the red cells and put into aliquot tubes following centrifugation.
Specify dosage history. Do not collect sooner than eight hours after last dose. Time drawn must be written on label
Specify dosage history. Do not collect sooner than eight hours after last dose. Time drawn must be written on label
Transport Temperature
Refrigerated
Specimen Stability
Centrifuge within two hours of collection
Ambient: 48 hours Refrigerated: 48 hours Frozen: 7 days
Ambient: 48 hours Refrigerated: 48 hours Frozen: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples drawn in a tube with a separator gel will be rejected. The separator gel may cause falsely lower results.
Methodology
Immunoturbidimetric
Setup Schedule
Sunday-Saturday
Reference Range
Therapeutic: Arrhythmia: 0.5-1.1 ng/mL Congestive Heart Failure: 0.5-0.8 ng/mL
Toxic (Critical value): ≥2.1 ng/mL
Toxic (Critical value): ≥2.1 ng/mL
Clinical Significance
Digoxin therapy requires ~5-7 days (half-life ~ 36-48 hours). In renal failure, 15-20 days may be required to reach steady-state.
Trough levels are drawn immediately before the next scheduled dose. Trough levels are initially drawn 3-5 days after initiating therapy. Levels
are drawn 12-24 hours after a loading dose.
Consider monitoring renal function, electrolytes (K+, Mg++), heart rate
Trough levels are drawn immediately before the next scheduled dose. Trough levels are initially drawn 3-5 days after initiating therapy. Levels
are drawn 12-24 hours after a loading dose.
Consider monitoring renal function, electrolytes (K+, Mg++), heart rate
Performing Laboratory
West Virginia University Hospital, Inc.
Berkeley Medical Center Braxton County Memorial Camden Clark Medical Center Garrett Regional Medical Center Jackson General Hospital Jefferson Medical Center Princeton Community Hospital Potomac Valley Hospital Reynolds Memorial Hospital Summersville Regional Medical Center St. Joseph’s Hospital United Hospital Center Uniontown Hospital Wetzel County Hospital Wheeling Hospital
