AMYLOID PRECURSOR PROTEIN IMMUNOHISTOCHEMISTRY (IHC)

Message

This test is ordered by pathologists.

Test Code

1230300899

CPT Codes
88342-TC, primary, 88341-TC if additional IHC

Preferred Specimen

Tissue

Other Acceptable Specimens

Formalin- fixed, paraffin-embedded (FFPE) tissue block

Methodology
Immunohistochemistry (IHC) interpreted by a pathologist

FDA Status
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufactureer's instructions. Performance characteristics were verified by WVUH in a manner consistent with CLIA requirements.

Clinical Significance

Amyloid precursor protein (APP) IHC is used as an aid to identify APP in Alzheimer disease. APP is found in Alzheimer disease associated plaques, large pyramidal cells, neurons, astrocytes, and microglia. Histologic features of Alzheimer disease include abundant neurofibrillary tangles, neuropil threads, and neuritic or "senile" plaques. The main component of senile plaque amyloid is referred to as beta amyloid, which is derived from APP. The patient’s clinical history and results of other diagnostic tests should be considered when interpreting staining results.

Performing Laboratory
West Virginia University Hospitals, Inc.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.