CD163 IMMUNOHISTOCHEMISTRY (IHC)

Message

This test is ordered by pathologists.

Test Code

1230300898

CPT Codes
88342-TC, Primary; 88341-TC, if additional IHC

Preferred Specimen

Formalin-fixed, paraffin-embedded (FFPE) tissue block

Methodology
Immunohistochemistry (IHC) interpreted by a pathologist

FDA Status
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by WVUH in a manner consistent with CLIA requirements.

Clinical Significance

CD163 IHC is used to identify cells of monocytic/histiocytic lineage, which express CD163 late in maturation. CD163 is a scavenger receptor for the hemoglobin-haptoglobin complex that has better specificity for monocytic/histiocytic lineage compared to CD68. In normal lymphoid tissue, staining of histiocytes in the paracortex and follicle center (tingible body macrophages) is seen. CD163 IHC is usually negative in acute myeloid leukemias with monocytic differentiation.

Performing Laboratory
West Virginia University Hospitals, Inc.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.