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CYCLOSPORINE PEAK (C2)
MessageTrough levels are drawn prior to the next scheduled dose. Peak levels should be drawn 2 hrs post-dose.
Test Code
LAB304425
CPT Codes
80158
Preferred Specimen
One 3 mL lavender top tube
Pediatric: One lavender top microtainer
Pediatric: One lavender top microtainer
Instructions
Specify dosage history. Time drawn must be written on label.
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 24 hours Refrigerated: 7 days Frozen: not specified
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimen or serum samples
Methodology
Chemiluminescent Immunoassay
Setup Schedule
Sunday-Saturday Note: Testing will be performed twice per day; 12 noon and 8 pm (specimens must be received in the laboratory prior to the testing times in order to be run that day).
Reference Range
Therapeutic level: 800-1500 ng/mL (Peak)
Toxic level: ≥1500 ng/mL
Toxic level: ≥1500 ng/mL
Clinical Significance
Monitoring whole blood cyclosporine concentration during therapy, particularly in individuals coadministered CYP3A4 substrates,
inhibitors, or inducers.
Adjusting dose to optimize immunosuppression while minimizing toxicity.
Evaluating patient compliance
inhibitors, or inducers.
Adjusting dose to optimize immunosuppression while minimizing toxicity.
Evaluating patient compliance
Performing Laboratory
West Virginia University Hospital, Inc.
