| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
TACROLIMUS (PROGRAF)
MessageCollect as a trough just prior to next dose.
Test Code
LAB304143
CPT Codes
80197
Preferred Specimen
One 3 mL lavender top tube, whole blood
Pediatric: One lavender top microtainer
Pediatric: One lavender top microtainer
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 24 hours
Refrigerated: 7 days
Frozen: 6 months
Refrigerated: 7 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimen or cadaveric specimen
Methodology
Chemiluminescent Immunoassay
Setup Schedule
Sunday-Saturday
Note: Testing will be performed twice per day; 12 noon and 8 pm (specimens must be received in the laboratory prior to the testing times in order to be run that day).
Monday-Friday: Additional testing performed at 7am- must be recieved in the laboratory before 6:30am.
Note: Testing will be performed twice per day; 12 noon and 8 pm (specimens must be received in the laboratory prior to the testing times in order to be run that day).
Monday-Friday: Additional testing performed at 7am- must be recieved in the laboratory before 6:30am.
Reference Range
Therapeutic level: 5.0 - 14.0 ng/mL
Toxic (Critical) level: >=15.0 ng/mL
Toxic (Critical) level: >=15.0 ng/mL
Clinical Significance
Monitoring whole blood tacrolimus concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers.
Adjusting dose to optimize immunosuppression while minimizing toxicity.
Evaluating patient compliance.
Adjusting dose to optimize immunosuppression while minimizing toxicity.
Evaluating patient compliance.
Performing Laboratory
West Virginia University Hospital, Inc.
