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CYCLOSPORINE, TROUGH
MessageTrough levels are drawn prior to the next scheduled dose. Peak levels should be drawn 2 hrs post-dose.
Test Code
LAB304110
CPT Codes
80158
Preferred Specimen
One 3 mL lavender top tube
Pediatric: One lavender top microtainer
Pediatric: One lavender top microtainer
Instructions
Specify dosage history, collect trough level. Time drawn must be written on label. Specimen must be received in the laboratory before noon in order to be run that day.
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 24 hours Refrigerated: 7 days Frozen: not specified
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimen or serum samples
Methodology
Chemiluminescent Immunoassay
Setup Schedule
Sunday-Saturday Note: : Testing will be performed twice per day; 12 noon and 8 pm (specimens must be received in the laboratory prior to the testing times in order to be run that day).
Reference Range
Therapeutic level: 100-375 ng/mL (Trough)
Toxic level: ≥650 ng/mL
Toxic level: ≥650 ng/mL
Clinical Significance
Monitoring whole blood cyclosporine concentration during therapy, particularly in individuals coadministered CYP3A4 substrates,
inhibitors, or inducers.
Adjusting dose to optimize immunosuppression while minimizing toxicity.
Evaluating patient compliance
inhibitors, or inducers.
Adjusting dose to optimize immunosuppression while minimizing toxicity.
Evaluating patient compliance
Performing Laboratory
West Virginia University Hospital, Inc.
