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ANTI-DOUBLE STRANDED DNA AB
Test CodeLAB304159
Alias/See Also
IFA DNA DOUBLE-STRANDED (DSDNA) ANTIBODIES by Crithidia
CPT Codes
86255
Preferred Specimen
One 5 mL gold top tube
Other Acceptable Specimens
Red top tube
Instructions
Sample must be centrifuged within two hours of collection. Serum/plasma must be removed from the red cells and put into aliquot tubes following centrifugation. Required for Testing: 0.5 mL serum
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 72 hours Frozen: not specified
Methodology
Automated Indirect Immunofluorescence on Crithidia substrate
Setup Schedule
Monday, and Thursday
Report Available
Titer reported if positive.
Reference Range
Negative
Clinical Significance
This test, performed by indirect immunofluorescence, is used by specialists to evaluate patients with positive antinuclear antibody results and clinical suspicion of lupus, as well as other systemic autoimmune rheumatic diseases (SARDs).
This is the primary sub-serology test used to evaluate patients with signs and symptoms of systemic lupus erythematosus (SLE). It is also used to monitor patients with documented SLE for changes in disease activity, and to assess risk for lupus nephritis. Double-stranded DNA antibody testing - as for other autoimmune subserology testing - should only be performed if a prior positive ANA test result has been obtained. Few sub-serology tests have value in ANA-negative patients.
This is the primary sub-serology test used to evaluate patients with signs and symptoms of systemic lupus erythematosus (SLE). It is also used to monitor patients with documented SLE for changes in disease activity, and to assess risk for lupus nephritis. Double-stranded DNA antibody testing - as for other autoimmune subserology testing - should only be performed if a prior positive ANA test result has been obtained. Few sub-serology tests have value in ANA-negative patients.
Performing Laboratory
West Virginia University Hospital, Inc.
