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EPSTEIN BARR VIRUS (EBV) ANTIBODY PROFILE, SERUM
MessageDiagnosing infectious mononucleosis when a mononucleosis screening test is negative and either infectious mononucleosis or a complication of EBV is suspected
Test Code
LAB3044361
Includes
EBV Viral Capsid IgM, EBV Viral Capsid IgG, EBV Nuclear Antigen IgG
Preferred Specimen
Gold Top Tube
Pediatric: 2 Gold top microtainers
Pediatric: 2 Gold top microtainers
Other Acceptable Specimens
Red Top Tube
Instructions
Centrifuge within 1 hour of collection. Separate serum from cells if Red Top tube.
Reguiered for testing: 0.5 mL serum.
Reguiered for testing: 0.5 mL serum.
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated 2-8° C for 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Failure to fully fill tube
Methodology
Multiplex Immunoassay on BioPlex 2200
Setup Schedule
Tuesday- Thursday Dayshift
Reference Range
Qualitative
Clinical Significance
At least 90% of adults in most populations have been previously infected with EBV and will be positive for VCA IgG and EBNA antibody.
EBNA antibody develops 6-8 weeks after primary infection and persists for life. Presence of VCA IgM antibodies alone suggests
recent primary infection with EBV or virus reactivation without an IgG response.
EBNA antibody develops 6-8 weeks after primary infection and persists for life. Presence of VCA IgM antibodies alone suggests
recent primary infection with EBV or virus reactivation without an IgG response.
| VCA IgG | VCA IgM | EBNA IgG | Interpretation |
| - | - | - | No prior exposure to EBV |
| - | + | - | Recent prior exposure with EBV or virus reactive without IgG response |
| + | - | + | Prior exposure to EBV |
| + | + | + | Prior exposure to EBV with recovery or virus reactivation |
Performing Laboratory
West Virginia University Hospital, Inc.
