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SUBXONE CONFIRMATORY/ DEFINITIVE, URINE, BY LC-MS/MS
MessageDefinitive compliance checks in patients prescribed buprenorphine, naloxone, and/or suboxone
Confirming presumptive positive screening results for buprenorphine
[Urine quantitative values do NOT correlate well with serum concentrations and should not be used for assessing dose efficacy or timing.]
Confirming presumptive positive screening results for buprenorphine
[Urine quantitative values do NOT correlate well with serum concentrations and should not be used for assessing dose efficacy or timing.]
Test Code
LAB1230624
CPT Codes
80307
Includes
Adulteration testing for urine creatinine is provided at no-charge and included in the report.
Preferred Specimen
Urine, random specimen clean plastic collection cup.
Minimum Volume
5mL
Instructions
Specimens collected in clean plastic collection cups are acceptable. Store refrigerated for best stability.
Transfer mixed urine specimen to a labeled red top tube and deliver to Chemistry department for track-based processing, adulteration testing,
and aliquoting for use in the mass spectrometry section.
Transfer mixed urine specimen to a labeled red top tube and deliver to Chemistry department for track-based processing, adulteration testing,
and aliquoting for use in the mass spectrometry section.
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 24 hours Refrigerated: 10 days
Methodology
LS-MS/MS
Setup Schedule
Monday - Friday dayshift
Reference Range
Negative
Clinical Significance
Quantitative/definitive detection of both buprenorphine (and its primary metabolite, norbuprenorphine) and naloxone, with flexible interpretations to give results for true exposures to suboxone, buprenorphine, and naloxone, and simulated compliance (aka, film dipping or pill-shaving) for buprenorphine and suboxone. Quantitative results are only provided for positive results; negative results will have an interpretation of “Negative” and a component result of “Not detected”.
All results require interpretation with the patient’s clinical context (ie, disease states) in mind. Creatinine: results <30 mg/dL generally suggest that the specimen is overly dilute. This can result in falsely low drug screen results.
Cutoffs:
Buprenorphine, 10 ng/mL
Naloxone, 5 ng/mL
Norbuprenorphine, 10 ng/mL
All results require interpretation with the patient’s clinical context (ie, disease states) in mind. Creatinine: results <30 mg/dL generally suggest that the specimen is overly dilute. This can result in falsely low drug screen results.
Cutoffs:
Buprenorphine, 10 ng/mL
Naloxone, 5 ng/mL
Norbuprenorphine, 10 ng/mL
Performing Laboratory
West Virginia University Hospitals, Inc
Additional Information
Test Change Notification
