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CHROMATIN (NUCLEOSOMAL) ANTIBODY
MessageTest Code
LAB1234001
CPT Codes
86235
Includes
Chromatin antibodies are synonymous with histone antibodies. Separate orders for these two tests are not suggested.
Preferred Specimen
Gold Top Tube
Pediatric: 2 Gold top microtainers
Pediatric: 2 Gold top microtainers
Other Acceptable Specimens
Red Top Tube
Instructions
Centrifgue within 1 hour of collection. Separate serum from cells if Red Top Tube.Aliquot 0.5 mL serum
Required for testing: 0.5 mL
Required for testing: 0.5 mL
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated 2-8°C for 7days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Failure to fully fill tube.
Methodology
Multiplex Immunoassay
Setup Schedule
Monady - Friday Dayshift
Reference Range
Negative
Clinical Significance
Chromatin Antibodies play a central role in the autoimmune response if systemic lupus erythematosus (SLE), and are common sub-serology
findings in other connective tissue disease workups. Chromatin antibodies recognize histone/dsDNA complexes common to cells in a
non-replicating state. Antinuclear sub-serology testing is NOT suggested unless a positive immunofluorescence result is obtained on initial ANA testing. Frequency of these antibodies in the non-diseased population is unknown and positivity does not necessarily suggest that a connective
tissue disease is present.
findings in other connective tissue disease workups. Chromatin antibodies recognize histone/dsDNA complexes common to cells in a
non-replicating state. Antinuclear sub-serology testing is NOT suggested unless a positive immunofluorescence result is obtained on initial ANA testing. Frequency of these antibodies in the non-diseased population is unknown and positivity does not necessarily suggest that a connective
tissue disease is present.
Performing Laboratory
West Virginia University Hospital, Inc.
