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OPIOID TOXIDROME CONFIRMATORY/DEFINITIVE, URINE, BY LC-MS/MS
MessageDefinitive detection of potential opioids responsible for an opioid toxidrome presentation [Urine quantitative values do NOT correlate well with serum concentrations and should not be used for assessing dose efficacy or timing.]
Test Code
LAB1230617
CPT Codes
80307
Includes
Quantitative/definitive detection of buprenorphine, codeine, dihydrocodeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, naloxone, oxycodone, oxymorphone, tramadol, and their major metabolites. Quantitative results are only provided for positive results; negative results will have an interpretation of “Negative” and a component result of “Not detected”. [Urine quantitative values do NOT correlate well with serum concentrations and should not be used for assessing dose efficacy or timing.]
Adulteration testing is provided at no-charge and includes urine creatinine
Adulteration testing is provided at no-charge and includes urine creatinine
Preferred Specimen
Urine, random specimen clean plastic collection cup
Pediatric: 3mL
Pediatric: 3mL
Minimum Volume
5mL
Required for Testing: 3mL
Required for Testing: 3mL
Instructions
Specimens collected in clean plastic collection cups are acceptable. Store refrigerated for best stability.
Transfer mixed urine specimen to a labeled red top tube and deliver to Chemistry department for track-based processing, adulteration testing,
and aliquoting for use in the mass spectrometry section.
Transfer mixed urine specimen to a labeled red top tube and deliver to Chemistry department for track-based processing, adulteration testing,
and aliquoting for use in the mass spectrometry section.
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 24 hours Refrigerated: 10 days
Methodology
LC-MS/MS
Setup Schedule
Monday - Friday dayshift
Reference Range
Negative
Clinical Significance
Cutoffs:
Buprenorphine, 10 ng/mL
Codeine, 25 ng/mL
Dihydrocodeine, 25 ng/mL
EDDP, 50 ng/mL
Fentanyl, 0.5 ng/mL
Hydrocodone, 25 ng/mL
Hydromorphone, 25 ng/mL
Methadone, 50 ng/mL
Morphine, 25 ng/mL
Naloxone, 5 ng/mL
Norbuprenorphine, 10 ng/mL
Norfentanyl, 2 ng/mL
Norhydrocodone, 25 ng/mL
Noroxycodone, 25 ng/mL
Oxycodone, 25 ng/mL
Oxymorphone, 25 ng/mL
Tramadol, 25 ng/mL
Buprenorphine, 10 ng/mL
Codeine, 25 ng/mL
Dihydrocodeine, 25 ng/mL
EDDP, 50 ng/mL
Fentanyl, 0.5 ng/mL
Hydrocodone, 25 ng/mL
Hydromorphone, 25 ng/mL
Methadone, 50 ng/mL
Morphine, 25 ng/mL
Naloxone, 5 ng/mL
Norbuprenorphine, 10 ng/mL
Norfentanyl, 2 ng/mL
Norhydrocodone, 25 ng/mL
Noroxycodone, 25 ng/mL
Oxycodone, 25 ng/mL
Oxymorphone, 25 ng/mL
Tramadol, 25 ng/mL
Performing Laboratory
West Virginia University Hospitals, Inc.
Additional Information
Test Change Notification
