ROS1 (6Q22) REARRANGEMENT, FISH, TISSUE

Message

Identifying c-ros oncogene 1 (ROS1) gene rearrangements in patientswith late-stage, lung adenocarcinomas that are negative for epidermal
growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements.

Test Code

1230300678

CPT Codes
Varies

Preferred Specimen

Preferred: Tissue block: Submit aformalin-fixed, paraffin-embedded (FFPE) tumor tissue block. Blocks prepared with alternative fixation methods may be acceptable, provide fixation method used.
Acceptable: Slides: Four consecutive, unstained, 5 micron-thick sections placed on positively charged slides, and 1 hematoxylin and eosin-stained slide.

Instructions

Provide a reason for referral and pathology report with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.

Transport Temperature

Transport Temperature: Ambient or refrigerated (prolonged transport conditions)

Methodology
Fluorescent In Situ Hybridization (FISH)

FDA Status
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by WVUH in a manner consistent with CLIA requirements.

Setup Schedule

Samples processed Monday through Saturday. Results reported Monday through Friday.

Reference Range

An interpretive report will be provided.

Clinical Significance

This test does not include a pathology consult. If a pathology consultation is requested, PATHC / Pathology Consultation should be
ordered and the appropriate FISH test will be ordered and performed at an additional charge. This test includes a charge for application of the first probe set (2 FISH probes) and professional interpretation of results. Additional charges will be incurred for all reflex probes performed.
Analysis charges will be incurred based on the number of cells analyzed per probe set. If no cells are available for analysis, no analysis charges will be incurred.

Performing Laboratory
West Virginia University Hospital, Inc.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.