HPV DNA TISSUE TESTING

Message

Test information is available on the Neogenomics Website This test may be used for testing malignancies of the head & neck (see HPV testing guidelines)

Test Code

CPT Codes
87624 (see Neogenomics website for up to date information)

Preferred Specimen

FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides with tissue area approximately
100 mm2 cut at thickness of 5-10 microns. Please use positively charged slides and 10% NBF fixative. Do not use zinc fixatives.

Methodology
HPV DNA Tissue Testing is peformed on FFPE tissue. It uses PCR and fragment analysis for qualitative detection and genotyping of human papillomavirus (HPV) low risk types 6/11 and high risk types 16, 18, 31, 33, 45,

Report Available

Neogenomics Turnaround Time: 5-7 days

Clinical Significance

HPV DNA testing on FFPE tissue in head and neck squamous cell carcinomas (HNSCC), anogenital, and cervical lesions provides a complementary or alternative method to testing by p16 IHC or HPV ISH. In anogenital specimens, testing can distinguish presence of low risk HPV types 6 and 11, associated with benign warts, from high-risk types which are associated with approximately 90% of anal cancers, 40% of vaginal cancers, and 40% of penile cancers. HPV is detected in up to 60-70% of oropharyngeal cancers and approximately 30% of HNSCC overall. HPV status serves as a prognostic marker head and neck cancer. Patients with HPV-positive cases have improved response to treatment and longer survival than patients with HPV negative tumors in clinical trials.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.