| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
DOG-1, IMMUNOHISTOCHEMISTRY (IHC)
MessageThis test is ordered by pathologists.
Test Code
1694339445
CPT Codes
88342-TC, Primary;88341-TC, if additional IHC
Preferred Specimen
Tissue: Formalin-fixed, paraffin-embedded (FFPE) tissue block and cytology (cell block) specimens.
Methodology
Immunohistochemistry (IHC)
FDA Status
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufactureer's instructions. Performance characteristics were verified by WVUH in a manner consisten with CLIA requirements.
Clinical Significance
DOG-1 IHC staining is primarily used to help identify gastrointestinal stromal tumors (GIST).
DOG-1 (discovered on GIST-1) functions in the regulation of cellular survival & proliferation as well as GI smooth muscle cholinergic activity.
DOG-1 IHC shows similar sensitivity and specificity for GIST as CD117 IHC, including those harboring KIT mutations (80-90%) as well as the
“wild-type” variant which lack KIT and PDGFRA mutations and are SDH-deficient. This latter tumor subtype is most common in the pediatric population. GIST with PDGFRA mutations (~10%) are typically negative for CD117 but are positive for DOG-1 in the majority of cases. Like CD117, DOG-1 is negative in schwannoma, leiomyoma/leiomyosarcoma, desmoid, melanoma and solitary fibrous tumor.
DOG-1 IHC is a cytoplasmic and membranous stain.
DOG-1 (discovered on GIST-1) functions in the regulation of cellular survival & proliferation as well as GI smooth muscle cholinergic activity.
DOG-1 IHC shows similar sensitivity and specificity for GIST as CD117 IHC, including those harboring KIT mutations (80-90%) as well as the
“wild-type” variant which lack KIT and PDGFRA mutations and are SDH-deficient. This latter tumor subtype is most common in the pediatric population. GIST with PDGFRA mutations (~10%) are typically negative for CD117 but are positive for DOG-1 in the majority of cases. Like CD117, DOG-1 is negative in schwannoma, leiomyoma/leiomyosarcoma, desmoid, melanoma and solitary fibrous tumor.
DOG-1 IHC is a cytoplasmic and membranous stain.
Performing Laboratory
West Virginia University Hospitals, Inc.
