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ARGINASE-1, IMMUNOHISTOCHEMISTRY (IHC)
MessageThis test is ordered by pathologists.
Test Code
1694339447
CPT Codes
88342-TC, Primary;88341-TC, if additional IHC
Preferred Specimen
Formalin-fixed, paraffin-embedded (FFPE) tissue block
Methodology
Immunohistochemistry (IHC)
FDA Status
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufactureer's instructions. Performance characteristics were verified by WVUH in a manner consistent with CLIA requirements.
Clinical Significance
Arginase-1 IHC staining is primarily used to aid in diagnosing hepatocellular neoplasms.
Arginase-1 is a urea cycle metalloenzyme expressed in normal human liver with a high degree of specificity. Arginase is more sensitive for
hepatocellular carcinoma (HCC) than Hepar-1 (~90% vs ~80%), but may be expressed in a small subset of cholangiocarcinoma. Therefore,
in combination with other stains, Arginase is useful in determining hepatocellular origin and in distinguishing HCC from other neoplasms
(primary or metastatic).
Arginase-1 is strongly & diffusely expressed in normal liver. In addition to cytoplasmic reactivity, patchy nuclear reactivity is also often present
in hepatocytes. Likewise in HCC, Arginase-1 shows cytoplasmic or cytoplasmic plus nuclear positivity, but may be variable in intensity.
Reactivity is not observed in bile duct epithelial cells, sinusoidal endothelial cells, Kupffer cells, or vascular endothelial cells.
Arginase-1 is a urea cycle metalloenzyme expressed in normal human liver with a high degree of specificity. Arginase is more sensitive for
hepatocellular carcinoma (HCC) than Hepar-1 (~90% vs ~80%), but may be expressed in a small subset of cholangiocarcinoma. Therefore,
in combination with other stains, Arginase is useful in determining hepatocellular origin and in distinguishing HCC from other neoplasms
(primary or metastatic).
Arginase-1 is strongly & diffusely expressed in normal liver. In addition to cytoplasmic reactivity, patchy nuclear reactivity is also often present
in hepatocytes. Likewise in HCC, Arginase-1 shows cytoplasmic or cytoplasmic plus nuclear positivity, but may be variable in intensity.
Reactivity is not observed in bile duct epithelial cells, sinusoidal endothelial cells, Kupffer cells, or vascular endothelial cells.
Performing Laboratory
West Virginia University Hospitals, Inc.
