KI 67 (MIB-1), IMMUNOHISTOCHEMISTRY (IHC)

Message

This test is ordered by pathologists.
Determining proliferation of tumor cells in paraffin-embedded tissue blocks from patients diagnosed with carcinoma.

Test Code

1230300850

CPT Codes
88360 (quantitative)

Preferred Specimen

Tissue

Methodology
Immunohistochemistry

FDA Status
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by WVUH in a manner consistent with CLIA requirements.

Clinical Significance

Ki-67 (MIB-1 clone) is a monoclonal antibody that reacts with cells undergoing DNA synthesis by binding to the Ki-67 antigen, a marker known to be expressed only in proliferating cells. By measuring the amount of tumor cells expressing Ki-67, an estimate of DNA synthesis can be determined. Studies suggest that Ki-67 (MIB-1) analysis of paraffin-embedded tissue specimens may provide useful prognostic information in various tumor types.

Performing Laboratory
West Virginia University Hospitals, Inc

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.