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PROCALCITONIN ALGORITHM
MessageNon WVUH Sites Procalcitonin (LAB3041196) is non-algorithm, single test.
Quantitative tmeasure of procalcitonin used for patient with suspected lower respiratory tract infection and/or systemic bacterial infection/
sepsis to:
1. assist in diagnostic confirmation
2. with serial trending, to gauge prognosis and response to therapy
Please see the link under Additional Information for the Test Change Notification.
Quantitative tmeasure of procalcitonin used for patient with suspected lower respiratory tract infection and/or systemic bacterial infection/
sepsis to:
1. assist in diagnostic confirmation
2. with serial trending, to gauge prognosis and response to therapy
Please see the link under Additional Information for the Test Change Notification.
Test Code
LAB1230628
CPT Codes
84145 x2
Preferred Specimen
Light green top, Red top tube, Gold top tube, or Dark green top tube
Pediatric: Two light green top microtainers, (Red, Gold, Dark Green microtainers are also acceptable.
Pediatric: Two light green top microtainers, (Red, Gold, Dark Green microtainers are also acceptable.
Minimum Volume
Required for Testing: 1.0 mL serum
Instructions
Sample must be centrifuged within one hour of collection. Seperate serum from cells and aliquot 1.0 mL serum.
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 8 hours
Refrigerated: 48 hours Frozen: 15 days
Refrigerated: 48 hours Frozen: 15 days
Methodology
CMIA, Chemiluminescent microparticle Assay
Setup Schedule
Sunday - Saturday
Reference Range
<0.50 ng/mL
Clinical Significance
Systemic bacterial infection/sepsis:
<0.5 ng/mL – Low risk
0.5-2.0 ng/mL – Indeterminate risk, clinical correlation required.
>2.0 ng/mL – High risk
Lower respiratory tract infection (LRTI):
<0.25 ng/mL – Low risk
0.25-0.5 ng/mL – Indeterminate risk, clinical correlation required.
>0.5 ng/mL – High risk
<0.5 ng/mL – Low risk
0.5-2.0 ng/mL – Indeterminate risk, clinical correlation required.
>2.0 ng/mL – High risk
Lower respiratory tract infection (LRTI):
<0.25 ng/mL – Low risk
0.25-0.5 ng/mL – Indeterminate risk, clinical correlation required.
>0.5 ng/mL – High risk
- Procalcitonin results must be interpreted in the context of patient’s clinical status. Follow-up testing to assess value trends should be considered for patients with unstable clinical course and/or for reevaluation of patient management.
- Trauma, non-infectious systemic inflammation, active autoimmunity, and recent surgery can cause elevated PCT results. Newborns can also have elevated PCT results during the first 72 hours of life.
- This assay is subject to “hook effect” at results >2,500 ng/mL. If results are lower than expected for the clinical presentation (ie, <10 ng/mL for presentations consistent with sepsis or septic shock), please contact the laboratory within 24 hours and request a dilution/ result confirmation. Very high (>10,000 ng/mL) PCT results have been reported for severe cases.
- Repeat PCT testing is indicated in 6 to 24 hours if clinical suspicion for sepsis is high but initial PCT result is not or only moderately elevated (ie, >0.5 but <2.0 ng/mL). A repeated value that is increased may suggest sepsis evolution. A repeated value that is lower or unchanged suggests a non-bacterial etiology.
- Physiologic halfâlife of PCT is approximately 24 hours. Renal failure could elevate PCT results due to decreased clearance.
- Procalcitonin Kinetics
Performing Laboratory
West Virginia University Hospital, Inc.
Berkeley Medical Center Braxton County Memorial Camden Clark Medical Center Jackson General Hospital Jefferson Medical Center Potomac Valley Hospital Reynolds Memorial Hospital Summersville Regional Medical Center St. Joseph’s Hospital United Hospital Center
Additional Information
Test Change Notification
