ESTRADIOL

Test Code

LAB523

CPT Codes
82670

Preferred Specimen

One 4.5 mL light green top tube
Pediatric: One light green top microtainer

Other Acceptable Specimens

Red top tube, or gold top tube

Instructions

Limitation for the Estradiol: Estradiol results from this method (Abbott immunoassay) are falsely and dramatically elevated in patients taking mifepristone (RU-486) for up to 2 weeks, based on the bioavailability of this compound. Please contact thechemistry laboratory with questions.
Sample must be centrifuged within two hours of collection. Serum/plasma must be removed from the red cells and put into aliquot tubes following centrifugation.

Transport Container

Transport Temperature

Refrigerated

Specimen Stability

Centrifuge within 2 hours after collection
Ambient: 24 hours Refrigerated: 7 days Frozen: not specified

Methodology
Chemiluminescent Immunoassay

Setup Schedule

Sunday-Saturday

Reference Range

Males	<24-44 pg/mL
Females
Follicular	<24-251 pg/mL
Peri-ovulatory	38-649 pg/mL
Mid-luteal	<24-312 pg/mL
Postmenopausal (on HRT)	<24-144 pg/mL
Postmenopausal (not on HRT)	<24-28 pg/mL

Clinical Significance

Evaluating hypogonadism and oligo-amenorrhea in females
Assessing ovarian status, including follicle development, for assisted reproduction protocols
Monitoring of estrogen replacement therapy in hypogonadal premenopausal women in conjunction with LH
Evaluating feminization, including gynecomastia, in males
Diagnosing estrogen-producing neoplasms in males, and, to a lesserdegree, females
As part of evaluation of precocious and delayed puberty in females, and, to a lesser degree, males
As part of evaluation of suspected disorders of sex steroid metabolism, eg, aromatase deficiency and 17 alpha-hydroxylase deficiency
As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men
Monitoring low-dose female hormone replacement therapy in postmenopausal women
Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)

Performing Laboratory
West Virginia University Hospital, Inc.
Berkeley Medical Center
Camden Clark Medical Center
United Hospital Center
Wheeling Hospital

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.