Neurology Antibody, Line Blot

Test Code

93892

Alias/See Also

LAB15235

CPT Codes
84182 (x11), 86341

Includes

ANNA1 (HU) AB, ANNA2 (RI) AB, PCA1 (YO) AB, MA2/TA AB, CRMP5/CV2 AB, AMPHIPHYSIN AB, GAD65 AB, RECOVERIN AB, AGNA/SOX1 AB, TITIN AB, ZIC4 AB, PCA TR (DNER) AB

Preferred Specimen

0.5 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.3 mL

Other Acceptable Specimens

CSF collected in a sterile, screw-cap container

Instructions

Shipping refrigerated (cold packs), or frozen is acceptable.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum Separator Tube (SST)

Methodology
Line Blot

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Wed, Fri; Report available: 8 days

Reference Range

ANNA1 (Hu) Ab, LB	<11 SI
ANNA2 (Ri) Ab, LB	<11 SI
PCA1 (Yo) Ab, LB	<11 SI
Ma2/Ta Ab, LB	<11 SI
CRMP5/CV2 Ab, LB	<11 SI
Amphiphysin Ab, LB	<11 SI
GAD65 Ab, LB	<11 SI
Recoverin Ab, LB	<11 SI
AGNA/SOX1 Ab, LB	<11 SI
Titin Ab, LB	<11 SI
Zic4 Ab, LB	<11 SI
PCA Tr (DNER) Ab, LB	<11 SI

Clinical Significance

Western line blot aids in the identification of specific anti-neuronal autoantibodies which can help establish a paraneoplastic syndrome diagnosis and may aid identification of the likely underlying tumor. The most commonly associated malignancies include small cell lung, breast and ovarian cancers, and hematologic malignancies. Clinical presentation of a given antibody may differ amongst patients; different antibodies may cause similar or identical clinical presentations. Paraneoplastic antibodies may be found in the absence of identifiable tumor.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.