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NMO Spectrum Evaluation (AQP4 with Reflex to MOG), Serum
Test Code38312
CPT Codes
86052
Includes
If the Aquaporin 4 Antibody, Serum is positive, then AQP4 Antibody, Titer, Serum will be performed at an additional charge (CPT code: 86052).
If the Aquaporin 4 Antibody, Serum is negative, then MOG Antibody, CBA, Serum will be performed at an additional charge (CPT code: 86362.
If the MOG Antibody, CBA, Serum is positive, then MOG Antibody, Titer, Serum will be performed at an additional charge (CPT code: 86362).
If the Aquaporin 4 Antibody, Serum is negative, then MOG Antibody, CBA, Serum will be performed at an additional charge (CPT code: 86362.
If the MOG Antibody, CBA, Serum is positive, then MOG Antibody, Titer, Serum will be performed at an additional charge (CPT code: 86362).
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube • Gross hemolysis • Grossly lipemic
Methodology
Cell-based Immunofluorescence Assay
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Thursday, Sunday Morning
Report available: 8 Days
Report available: 8 Days
Reference Range
Aquaporin 4 Ab, CBA, Serum | Negative |
Aquaporin 4 Ab, Titer, Serum | <1:10 Titer |
MOG Ab, CBA, Serum | Negative |
MOG Ab, Titer, Serum | <1:10 Titer |
Clinical Significance
NMO (neuromyelitis optica, Devic disease) is an immune- mediated chronic inflammatory disease that predominantly affects the optic nerve and spinal cord and presents with optic neuritis (ON) and myelitis. Limited forms of this disease, such as isolated ON, brainstem encephalitis and longitudinal extensive transverses myelitis (LETM), have been referred to as NMO spectrum disorders (NMOSD). NMO was originally thought to be a variant of multiple sclerosis but is now recognized as a distinct disease. The presence of serum antibodies against aquaporin-4 (AQP4) or myelin oligodendrocyte glycoprotein (MOG-IgG) is associated with NMO and NMOSD.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |