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TRAUMATIC BRAIN INJURY
MessageThis test is orderable only for Emergency Department patients and inpatients.
Test Code
LAB123209
Alias/See Also
TBI
CPT Codes
607881 (HCHG TBI Marker)
Preferred Specimen
One 4mL lavender top tube
Instructions
Collection tubes should be processed within 2 hours of collection to separate the clot / red blood cells from the plasma/serum.
Transport Temperature
See specimen stability
Specimen Stability
Stabilities listed are for plasma and whole blood.
- Ambient: 8 hours
- Refrigerated: 8 hours, on cells. If removed from cells 7 days and must be recentrifuged.
- Frozen: 1 month removed from cells
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolyzed; improperly processed or stored
Methodology
Chemiluminescent Immunoassay
Setup Schedule
Monday- Sunday
Reference Range
- TBI: Negative
- GFAP: 6.6-70.9 pg/mL
- UCH-L1: 44.7-226.8 pg/mL
Clinical Significance
The following comment is attached to TBI interpretation result:
‘This interpretation is based on the cutoffs of 35.0 pg/mL for GFAP and 400.0 pg/mL for UCH-L1. The interpretation result is used, in conjunction with other clinical information, to aid in the evaluation of patients, 18 years of age or older, presenting with suspected mild traumatic brain injury (Glasgow Coma Scale score 13-15) within 12 hours of injury, to assist in determining the need for a CT scan of the head. A negative test result is associated with the absence of acute intracranial lesions visualized on a head CT scan.’
‘This interpretation is based on the cutoffs of 35.0 pg/mL for GFAP and 400.0 pg/mL for UCH-L1. The interpretation result is used, in conjunction with other clinical information, to aid in the evaluation of patients, 18 years of age or older, presenting with suspected mild traumatic brain injury (Glasgow Coma Scale score 13-15) within 12 hours of injury, to assist in determining the need for a CT scan of the head. A negative test result is associated with the absence of acute intracranial lesions visualized on a head CT scan.’
Performing Laboratory
West Virginia University Hospital, Inc.
