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Hepatitis B Surface Antigen
MessagePerformed in the Chemistry Laboratory x5820.
10.2018
10.2018
Test Code
HBSAG
CPT Codes
87340
Preferred Specimen
Plasma from a green top (PST) tube
Minimum Volume
1 mL
Transport Container
Green Top (PST) tube
Transport Temperature
Room temperature
Specimen Stability
2 - 8 oC: 6 days
Methodology
Chemiluminescent Microparticle immunoassay (Abbott Architect)
Setup Schedule
This assay is performed Monday through Friday
Reference Range
Results reported as "NON-REACTIVE" or "SEE CONF" if result is reactive.
Confirmation testing is performed and is resulted as either "NOT CONFIRMED" or "CONFIRMED POSITIVE"
Confirmation testing is performed and is resulted as either "NOT CONFIRMED" or "CONFIRMED POSITIVE"
Clinical Significance
The hepatitis B virus surface antigen (HBsAg) is a marker of active infection and is the first marker to appear, about one to three weeks before the onset of symptoms. An additional test for antibodies against the hepatitis B virus core antigen (total Anti-HBc (HBCOR)) can help to interpret clinical situations in which HBsAg is non-reactive. HBsAg is non-reactive in uninfected individuals (total Anti-HBc (HBCOR) non-reactive) or after cleared infection (total Anti-HBc (HBCOR) reactive). In addition, HBsAg may be non-reactive early after exposure.
Typical patterns of Hepatitis B Virus related serum markers
| Marker | No exposure * | Acute infection | Chronic infection ** | Resolved infection | Vaccination |
| HBsAg (HBSAG) | NON-REACTIVE | CONFIRMED POSITIVE | CONFIRMED POSITIVE | NON-REACTIVE | NON-REACTIVE |
| Anti-HBs (HBSAB) | NON-REACTIVE | NON-REACTIVE | NON-REACTIVE | REACTIVE | REACTIVE |
| Anti-HBc IgM (HBCM) | NON-REACTIVE | REACTIVE | NON-REACTIVE | NON-REACTIVE | NON-REACTIVE |
| total Anti-HBc (HBCOR) | NON-REACTIVE | REACTIVE | REACTIVE | REACTIVE | NON-REACTIVE |
** in chronic Infection HBs Ag levels may wane and Anti-HBc IgM may recur in flares
