Hepatitis B Surface Antibody

Message

Performed in the Chemistry Laboratory x5820.
10.2018

Test Code

HBSAB

Alias/See Also

AUSAB

CPT Codes
86706

Preferred Specimen

Plasma from a green top (PST) tube

Minimum Volume

1 mL

Transport Container

Green Top (PST) tube

Transport Temperature

Room temperature

Specimen Stability

2 - 8 ^oC: 7 days

Methodology
Chemiluminescent Microparticle Immunoassay

Setup Schedule

This assay is performed Monday through Friday

Reference Range

NON-REACTIVE: < 8.0 mIU/mL
EQUIVOCAL: ≥ 8.0 to < 12.0 mIU/mL
REACTIVE: ≥ 12.0 Miu/mL

Note:
A non-reactive test result does not exclude the possibility of exposure to HBV.
Assay does not distinquish between vaccination and viral exposure

Clinical Significance

Antibodies against hepatitis B virus surface antigen (Anti-HBs) are a marker of immunity against hepatitis B virus infection, although depending on an appropriately high titer/concentration. An additional test for antibodies against the hepatitis B virus core antigen (total Anti-HBc (HBCOR)) can help to interpret clinical situations in which Anti-HBs are reactive. Anti-HBs appear one to three months after vaccination (total Anti-HBc (HBCOR) non-reactive) or after recovery from acute infection (total Anti-HBc (HBCOR) reactive).

Typical patterns of Hepatitis B Virus related serum markers

Marker	No exposure *	Acute infection	Chronic infection **	Resolved infection	Vaccination
HBsAg (HBSAG)	NON-REACTIVE	CONFIRMED POSITIVE	CONFIRMED POSITIVE	NON-REACTIVE	NON-REACTIVE
Anti-HBs (HBSAB)	NON-REACTIVE	NON-REACTIVE	NON-REACTIVE	REACTIVE	REACTIVE
Anti-HBc IgM (HBCM)	NON-REACTIVE	REACTIVE	NON-REACTIVE	NON-REACTIVE	NON-REACTIVE
total Anti-HBc (HBCOR)	NON-REACTIVE	REACTIVE	REACTIVE	REACTIVE	NON-REACTIVE

* consider recent exposure
** in chronic Infection HBs Ag levels may wane and Anti-HBc IgM may recur in flares

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.