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PT/PTT MIXING STUDY
Test CodeLAB2133
Alias/See Also
Mixing Study PT, Mxing Study PTT, Mixing Study Prothrombin Time, Mixing Study Protime, Mixing Study APTT
Preferred Specimen
Two 2.7 ml (2.7 ml minimum) sodium citrate (blue) whole blood. Refer to Hemostasis/Thrombosis Specimens section for specimen collection instructions.
Minimum Volume
4.0 ml (1.5 ml minimum) citrated platelet-poor plasma
Instructions
Discontinue coumadin therapy for 14 days, direct thrombin inhibitors, fondaparinux and heparin 2 days prior to collection
Specimen Stability
Unspun and uncapped: 4 hours room temp; Separated from cells: 4 hours room temp, 2 weeks frozen plasma
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Mechanical Clot Detection, Calculated
Setup Schedule
Mon- Sun
Reference Range
PT: 9.4-12.5 seconds. ** NOTE: Reference interval established using 3.2% sodium citrate
Clinical Significance
The Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) mixing study is used to investigate
the cause of a prolonged PT or APTT screening result that is not due to the presence of heparin or coumadin in the
specimen. Once it is clearly established that the PT and/or APTT is prolonged, the task is to determine whether the
prolongation is caused by factor deficiency or by the presence of an inhibitor
the cause of a prolonged PT or APTT screening result that is not due to the presence of heparin or coumadin in the
specimen. Once it is clearly established that the PT and/or APTT is prolonged, the task is to determine whether the
prolongation is caused by factor deficiency or by the presence of an inhibitor
Performing Laboratory
Piedmont Athens Regional
