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Valproic Acid
Test CodeLAB24
Alias/See Also
LAB24, Depakote, Depakene, VPA, 80164
CPT Codes
80164
Preferred Specimen
4.5 ml (600 ul min) lithium heparin (green); alternate-SST (gold) or Red (no additive)
Minimum Volume
1 ml (200 ul minimum) plasma; alternate-serum
Instructions
After centrifugation, if not in gel barrier tube, pour off plasma or serum into an aliquot tube
Transport Temperature
Room temp
Specimen Stability
Separated from cells: 8 hours room temp, 7 days refrigerated
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemoglobin: >800 mg/dL, Bilirubin: >30 mg/dL, Lipemia: >750 mg/dL
Methodology
Enzymatic Immunoassay (EIA)
Setup Schedule
Mon- Sun
Reference Range
Therapeutic: 50.0 – 150.0 ug/mL
Toxic: >150.0 ug/mL
Toxic: >150.0 ug/mL
Clinical Significance
Monitoring valproic acid concentrations in serum helps to individualize drug therapy for safe and effective control
of absence seizures, other generalized seizures, and partial seizures. Serum valproic acid monitoring is useful to
assess patient compliance, or to explain changes in seizure control or drug toxicity
of absence seizures, other generalized seizures, and partial seizures. Serum valproic acid monitoring is useful to
assess patient compliance, or to explain changes in seizure control or drug toxicity
Performing Laboratory
Piedmont Athens Regional
