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Vitamin B1 (Thiamine), Blood, LC/MS/MS
Test Code5042
CPT Codes
84425
Preferred Specimen
2 mL whole blood collected in an EDTA (lavender-top) tube, protected from light
Patient Preparation
Overnight fasting is required
Minimum Volume
1 mL
Instructions
Transfer whole blood to amber transport tube. If amber tube is not available, wrap tube in aluminum foil to protect from light. Freeze immediately.
Transport Container
Amber transport tube or foil wrapped tube - light-protected
Transport Temperature
Frozen
Specimen Stability
Room temperature: 8 hours
Refrigerated: 5 days
Frozen: 35 days
Refrigerated: 5 days
Frozen: 35 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature and not protected from light • Received refrigerated and not protected from light
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 2-3 days
Reference Range
78-185 nmol/L
Clinical Significance
Vitamin B1 is required for branched-chain amino acid and carbohydrate metabolism. Vitamin B1 deficiency is most often due to alcoholism or chronic illness. In the early stage, patients with vitamin B1 deficiency exhibit anorexia, irritability, apathy, and generalized weakness. Prolonged deficiency causes beriberi.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153