Cholinesterase, Serum, Plasma, RBC

Test Code

39481

CPT Codes
82480 (x2), 82482

Preferred Specimen

5 mL whole blood collected in an EDTA (lavender-top) tube and
1 mL plasma collected in an EDTA (lavender-top) tube and
1 mL serum

Minimum Volume

4 mL whole blood • 0.5 mL plasma • 0.5 mL serum

Instructions

Transfer plasma and serum to transport tubes and send refrigerated with whole blood.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Refrigerated: 7 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis

Methodology
Kinetic Spectrophotometric (KS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Fri; Report available: Next day

Limitations

Results may be depressed in patients who consume oral contraceptives. Hepatic disease may cause up to a 70% decrease in enzyme levels. Cholinesterase may be slightly elevated in patients with obesity or diabetes.

Reference Range

Cholinesterase, Serum
Male	3342-7586 IU/L
Female	2673-6592 IU/L
Cholinesterase, RBC	9572-15031 IU/L
Cholinesterase, Plasma
Male	3334-7031 IU/L
Female	2504-6297 IU/L

Clinical Significance

True Cholinesterase (RBC and plasma) activity is decreased in individuals with exposure to organophosphorous insecticides. True Cholinesterase, found in erythrocytes and nerve tissue, is responsible for inactivating acetylcholinesterase at nerve endings. With decreased enzyme activity, patients may display a range of nervous system dysfunction. Analysis of RBC and serum or plasma activity is useful in monitoring exposure and recovery.

Performing Laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.