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Phenobarbital Level
Test CodePHENOBARB - NCMC
CPT Codes
80184
Preferred Specimen
In-patient: 1 mL plasma from Green top (Lithium Heparin)
Out-patient: 1 mL serum from SST
Out-patient: 1 mL serum from SST
Minimum Volume
Other Acceptable Specimens
1.0 mL serum from Serum Gel or Red Top
Instructions
Draw immediately prior to next dose.
Specimen Stability
Specimen Type | Temperature | Time |
Plasma Li Hep | Refrigerated | 7 days |
Serum SST | Refrigerated | 7 days |
Red Top – Separated* | Refrigerated | 7 days |
*Centrifuge and aliquot into a plastic vial.
Methodology
Bichromatic Turbidimetric Rate - Particle Enhanced Turbidimetric Inhibition Immunassay (PETENIA)
Setup Schedule
Monday through Sunday; Continuously
Report Available
Same day
Reference Range
Therapeutic concentration: 10.0-30.0 µg/L
Critical value (automatic call-back): >59.9 µg/L
Critical value (automatic call-back): >59.9 µg/L
Clinical Significance
Phenobarbital is one of the most commonly used drugs for the treatment of grand mal, psychomotor epilepsy, and other forms of focal epilepsy. Monitoring of the serum level of the drug is essential in order to achieve maximal seizure control while maintaining minimal blood levels to avoid negative side effects. As with other anti-convulsant drugs, it is imperative that each patient’s dosage be individualized.
Performing Laboratory
North Colorado Medical Center Laboratory