ABL1 Kinase Domain Mutation

Test Code

ABL1KDM

Alias/See Also

Performed at NeoGenomics
ABL1 Kinase Domain Mutation

CPT Codes
81170 (ZBX5N)

Preferred Specimen

Draw 2.0 - 3.0ml Lav Top - whole blood or bone marrow

Instructions

See link below for specimen details, methodology, setup schedule and reference ranges.

Transport Container

Note: Use refrigerated cold pack for transport. Make sure cold pack is not in direct contact with specimen.
DO NOT FREEZE

Transport Temperature

Refrigerated

Methodology
Amplicon-based next-generation sequencing (NGS)

FDA Status
LDT

Report Available

Global: 10-12 days

Clinical Significance

BCR-ABL1 kinase domain point mutations are found in approximately 50% of chronic myelogeneous leukemia (CML) patients with treatment failure and progression. Mutation analysis can be helpful in the selection of subsequent tyrosine kinase inhibitor (TKI) therapy for patients with inadequate initial response to first-line or second-line TKI therapy

Additional Information
ABL1KDM

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.