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Chimerism Testing (Blood, BM) [ARC]
Message​Performed at American Red Cross
Test Code
CHIMERARC
Alias/See Also
CHIMERBLD; CHIMERBM
CPT Codes
81267, 81268
Preferred Specimen
7.0 mL EDTA Bone Marrow or 7.0 mL. EDTA or ACD Whole Blood
Minimum Volume
2.0 mL EDTA or ACD Whole Blood
Other Acceptable Specimens
For Blood: 4 Buccal Swabs
Transport Container
Appropriate boxes or Bubble wrap on any container to avoid breakage of the sample tube during transportation. Swab samples should be kept in paper envelope, not in plastic bags to avoid mold.
Transport Temperature
Ambient or Refrigerated
Specimen Stability
Whole Blood Ambient: 72 hours Whole Blood Refrigerated: 30 days Buccal swab (dry) Ambient: 1 week Buccal swab Frozen: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Incorrect labeling Damaged sample tubes Specimens collected in heparin
Methodology
PCR and fragment analysis. Analysis examines 24 STR markers covering 23 chromosomes.
FDA Status
Non-FDA Approved
Setup Schedule
Daily; M-F
Report Available
3 days
Limitations
Rare errors can occur due to primer site mutations.
Clinical Significance
This test establishes the donor genotype prior to transplant for use in post-transplant monitoring of the recipient.
