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Rheumatoid Arthritis Diagnostic Panel (RAPAN)
Test CodeLAB2385
Quest Code
17669
Alias/See Also
RAPAN
CPT Codes
86200,86431
Includes
Rheumatoid Factor
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Preferred Specimen
3 mL serum in gold top tube
Minimum Volume
1 mL
Other Acceptable Specimens
Plain red top tube or lavender top tube
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, lipemia
Methodology
Immunoturbidimetry • Immunoassay (IA)
Reference Range
| Rheumatoid Factor | <14 IU/mL |
| CCP Antibody, IgG | |
| Negative | <20 |
| Weak Positive | 20-39 |
| Moderate/Strong Positive | 40-59 |
| Strong Positive | >59 |
Clinical Significance
The combination of RF and anti-CCP antibodies provide greater specificity for the diagnosis of Rheumatoid Arthritis (RA). CCP antibodies may be present earlier than RF and often indicate increased erosive disease in RA.
Performing Laboratory
| Quest Diagnostics - South Region |
