A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Sirolimus (Rapamycin) (RAPAMY)
MessageOptimal time to draw specimen: 1 hr before next oral dose (12 hour trough).
Test Code
LAB875
Quest Code
36712
CPT Codes
80195
Preferred Specimen
2 mL whole blood collected in an EDTA (lavender-top) tube
Patient Preparation
Collect specimen 1 hour prior to next dose (12 hour trough)
Minimum Volume
1 mL
Instructions
Draw 2-3 mL of whole blood into lavender-top tube. Ship and store refrigerated. Shipping at ambient temperature (<25 C) is acceptable.
Transport Container
Preferred: Lavender top tube; Acceptable: Sodium heparin green top tube; Tan top tube (lead-free)
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimen
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Monday-saturday
Reference Range
3.0-18.0 ng/mL
Clinical Significance
Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.
Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA |
14225 Newbrook Drive |
Chantilly, VA 20151-2228 |