Sirolimus (Rapamycin) (RAPAMY)

Message

Optimal time to draw specimen: 1 hr before next oral dose (12 hour trough).

Test Code

LAB875

Quest Code

36712

CPT Codes
80195

Preferred Specimen

PATIENT PREPARATION:
COLLECT SPECIMEN 1 HOUR PRIOR TO NEXT DOSE (12 HOUR TROUGH).

2 ML WHOLE BLOOD COLLECTED IN AN EDTA (LAVENDER-TOP) TUBE

Minimum Volume

1 ML

Instructions

Draw 2-3 mL of whole blood into lavender-top tube. Ship and store refrigerated. Shipping at ambient temperature (<25 C) is acceptable.

Transport Container

Preferred: Lavender top tube; Acceptable: Sodium heparin green top tube; Tan top tube (lead-free)

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

ROOM TEMPERATURE: 5 DAYS
REFRIGERATED: 7 DAYS
FROZEN: 30 DAYS

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

CLOTTED WHOLE BLOOD

Methodology
Chromatography/Mass Spectrometry

Setup Schedule

Day shift Mon-Fri

Report Available

3 days

Reference Range

3.0-18.0 ng/mL

Clinical Significance

Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.

Performing Laboratory
QUEST DIAGNOSTICS-ATLANTA 1777 MONTREAL CIRCLE TUCKER GA 30084-6802

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.