Coccidioides Antibody, Complement Fixation and Immunodiffusion (COCCAB)

Test Code

LAB3447

Quest Code

15240

CPT Codes
86635, 86317

Preferred Specimen

2 mL serum in plain red top or gold top tube

Minimum Volume

0.3 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Grossly icteric

Methodology
Complement Fixation (CF) • Immunodiffusion (ID)

Limitations

False-negatives may occur in patients with solitary pulmonary lesions. Patients with active histoplasmosis may generate cross reactions. Elevated serum antibodies may be present in patients with meningeal coccidiocomycosis.

Reference Range

Coccidioides Ab, CF, Serum	<1:2
Coccidioides Ab (IgG), ID, Serum	Negative

Clinical Significance

Infection by Coccidioides immitis can produce a spectrum of disease, with most patients being asymptomatic and some developing disseminated disease, including pneumonia and meningitis

Performing Laboratory

Quest Diagnostics Nichols Institute-Chantilly VA

14225 Newbrook Drive

Chantilly, VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.