Aquaporin-4 Antibody (IgG), CBA (AQABIG)

Test Code

Quest Code

CPT Codes

Preferred Specimen
0.5 mL serum collected in a red-top tube (no gel) or CSF collected in a sterile, screw-cap container

Minimum Volume
0.3 mL

Transport Container
Transport tube

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum Separator Tube (SST®)

Cell Binding Assay-Immunofluorescence Assay

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Wednesday, friday

Reference Range

Clinical Significance
Antibody to Aquaporin 4 causes neuromyelitis optica (NMO), a demyelinating disease of the central nervous system often confused diagnostically with multiple sclerosis (MS) and/or transverse myelitis. NMO causes optic neuritis and transverse myelitis. Early discrimination between MS and NMO is important, as optimum treatment for both diseases may differ considerably.

Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.