Aldosterone, Adrenal Vein (ALDAV)

Test Code

Quest Code

CPT Codes

Preferred Specimen
1 mL serum collected in a red-top tube (no gel)

Minimum Volume
0.25 mL

Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top), EDTA (royal blue-top), sodium heparin (green-top), or lithium heparin (green-top) tube

Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum frozen. Do not submit glass tubes.
⁠⁠⁠⁠⁠⁠⁠Draw "upright" samples at least 1/2 hour after patient sits up.

Transport Container
Transport tube

Transport Temperature

Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST) • Moderate to gross hemolysis

Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Evening Mon, wed, fri

Reference Range
Reference ranges for the individual adrenal veins have not been established. Since results obtained on samples taken from various anatomical sites are variable, the following reference ranges apply only to measurements performed only on peripheral blood samples.

Upright 8:00-10:00 am≤28 ng/dL
Upright 4:00-6:00 pm≤21 ng/dL
Supine 8:00-10:00 am3-16 ng/dL
1-12 months**2-70 ng/dL
1-4 years**2-37 ng/dL
5-9 years≤9 ng/dL
10-13 years≤21 ng/dL
14-17 years≤35 ng/dL
Premature (31-35 weeks)**≤144 ng/dL
Term**≤217 ng/dL
Tanner Stages** 
II-III Males1-13 ng/dL
II-III Females2-20 ng/dL
IV-V Males3-14 ng/dL
IV-V Females4-32 ng/dL

**Pediatric data from J Clin Endocrinol Metab. 1992;75:1491 and J CLin Endocrinol Metab. 1989; 69;1133-1136.

Clinical Significance
Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body positions, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.

Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA
14225 Newbrook Drive
Chantilly, VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.