CLOPIDOGREL PLATELET FUNCTION ASSAY (PLAVIX) (CLOPFA)

Message

Kennestone: Specimen must be collected and hand-delivered to lab at room temperature. Notify lab staff and/or label packaging to indicate STAT. Do not send in pneumatic tube system.
Cobb: This test is performed at Kennestone and North Fulton. Contact the Cobb laboratory prior to collection to obtain instructions.

Test Code

LAB2201

Alias/See Also

CLOPFA

CPT Codes
80757

Preferred Specimen

Using the same venipuncture stick: collect one regular coag 3mL blue top tube, label with TB-1; then draw two 2mL blue top tubes (Greiner tubes only, with white trim), label first with TB-2, label the second with TB-3. CARRY ALL TUBES TO THE LAB. DO NOT SEND IN PNEUMATIC TUBE SYSTEM. KEEP UPRIGHT DURING TRANSPORT.

Instructions

Use 21 gauge needle or larger to draw blood for this specimen.

Transport Container

1 regular coag blue top tube and 2 blue top Greiner tubes with white inserts

Transport Temperature

Room temperature. Do not refrigerate or freeze.

Clinical Significance

Principle:
This assay (VerifyNow) is used to measure clopidogrel-induced inhibition of platelet aggregation. The system is designed to specifically assess blockade of the P2Y12 receptor. It is recommended that patients who have been receiving clopidogrel for whom a surgical procedure is contemplated should be off the drug for 5 days. This assay may also be used to assess for risk of perioperative bleeding.
Limitations:
Patients with inherited platelet disorders have not been studied. The test is not intended for these patients.
Interfering substances:
Patients who have been treated with Glycoprotein IIb/IIIa inhibitor drugs should not be tested until platelet function has recovered. The time period after discontinuation is about 14 days for abciximab and 48 hours for eptifibatide and tirofiban. Recovery time is variable among individuals and is longer in patients with renal dysfunction. Cilostazol may affect results with an average duration of inhibitory effect of 12 hours.

A number of commonly used drugs have no affect on the assay including: antioxidants, ACE inhibitors, antiarrhythmics, anticoagulants, aspirin, antidepressants, insulin, allopurinol, alcohol, beta blockers, bronchodilators, calcium channel blockers, betamethasone, lovastatin, NSAIDs, and streptokinase.

Assay performance is not affected by hematocrit values between 33-52% or platelet counts between 119,000-502,000/microL.

No interference is observed with triglyceride levels of 41-824 mg/dL, fibrinogen levels 171-599 mg/dL or cholesterol values 98-316 mg/dL.

Testing is available 24/7 and results will be available within 1 hour after receipt in the Laboratory.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.