TSH, High Sensitivity (TSHHS)

Test Code

Quest Code

Alias/See Also

CPT Codes

For patients 1 year of age or older, Free T4 will be performed at an additional charge (CPT code(s): 84439) when TSH result exceeds age/gender specific reference range.

Preferred Specimen
1 mL serum in gold top tube

Patient Preparation
Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks.
According to the assay manufacturer Siemens: "Samples containing fluorescein can produce falsely depressed values when tested with the Advia Centaur TSH3 Ultra assay."

Minimum Volume
0.7 mL

Other Acceptable Specimens
Plain red top tube; Sodium heparin (green-top) tube

This assay should only be ordered on patients 1 year of age or older. Orders on patients younger than 1 year will have a TSH only performed.

Transport Container
Serum Separator Tube (SST®)

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)


Reference Range
Premature Infants (28-36 Weeks)
1st Week of Life 0.20-27.90 mIU/L
Term Infants (>37 Weeks)
Serum or Cord Blood 1.00-39.00 mIU/L
1-2 Days 3.20-34.60 mIU/L
3-4 Days 0.70-15.40 mIU/L
5 Days-4 Weeks 1.70-9.10 mIU/L
1-11 Months 0.80-8.20 mIU/L
1-19 Years 0.50-4.30 mIU/L
≥20 Years 0.40-4.50 mIU/L
First Trimester 0.26-2.66 mIU/L
Second Trimester 0.55-2.73 mIU/L
Third Trimester 0.43-2.91 mIU/L
TSH levels decline rapidly during the first week of life in most children, but may remain transiently elevated in a few individuals despite normal free T4 levels. For proper interpretation of an abnormal TSH from a newborn thyroid screen, a Free T4 by Dialysis (test code 35167) or Total T4 (test code 867) should be considered.

Clinical Significance
For differential diagnosis of primary, secondary, and tertiary hypothyroidism. Also useful in screening for hyperthyroidism. This assay allows adjustment of exogenous thyroxine dosage in hypothyroid patients and in patients on suppressive thyroxine therapy for thyroid neoplasia.

Performing Laboratory
Quest Diagnostics - South Region

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.