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Catecholamines, Fractionated and Total, 24-Hour Urine (CATFUR)
MessageIt is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection however, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) may cause minimal or no interference. Patient should avoid tobacco, tea, coffee, and strenuous exercise for 8-12 hours prior to collection.
Test Code
LAB373
Quest Code
318
Alias/See Also
CATFUR
CPT Codes
82384
Includes
Dopamine, Epinephrine,Norepinephrine, Total Catecholamines (calculated)
Preferred Specimen
10 mL aliquot from a 24-hour collection preserved with 6N HCl at the start of collection. Unpreserved specimens must be frozen.
Patient Preparation
It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) may cause minimal or no interference.
Patient should avoid tobacco, tea, coffee, and strenuous exercise for 8-12 hours prior to collection.
Minimum Volume
5 mL
Other Acceptable Specimens
Aliquot from a 24-hour urine, unpreserved, with a pH ≤6, collected in a plastic 24-hour urine container
Instructions
Record total volume on both the transport container and the test requisition.
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature (if preserved) ; Frozen acceptable (if unpreserved)
Specimen Stability
Preserved urine
Room temperature: 7 days
Refrigerated: 30 days
Frozen: 49 days
Unpreserved urine
Room temperature: Unacceptable
Refrigerated: 30 days
Frozen: 49 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Preserved urine received refrigerated with pH >3 • Unpreserved urine received frozen with pH >6
Methodology
High Performance Liquid Chromatography (HPLC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Monday-friday
Limitations
Recent surgery, traumatic injury, upright posture, cold, anxiety, pain, clonidine withdrawal, and concurrent acute or chronic illness may produce elevated results.
Reference Range
Norepinephrine
3-8 Years 5-41 ug/24 h
9-12 Years 5-50 ug/24 h
13-17 Years 12-88 ug/24 h
>17 Years 15-100 ug/24 h
Epinephrine
3-8 Years 1-7 ug/24 h
9-12 Years < OR =8 ug/24 h
13-17 Years < OR =11 ug/24 h
>17 Years 2-24 ug/24 h
Dopamine
3-8 Years 80-378 ug/24 h
9-12 Years 51-474 µg/24 h
13-17 Years 51-645 µg/24 h
>17 Years 52-480 µg/24 h
Total Catecholamines
3-8 Years 9-51 µg/24 h
9-12 Years 9-71 µg/24 h
13-17 Years 13-90 µg/24 h
>17 Years 26-121 µg/24 h
3-8 Years 5-41 ug/24 h
9-12 Years 5-50 ug/24 h
13-17 Years 12-88 ug/24 h
>17 Years 15-100 ug/24 h
Epinephrine
3-8 Years 1-7 ug/24 h
9-12 Years < OR =8 ug/24 h
13-17 Years < OR =11 ug/24 h
>17 Years 2-24 ug/24 h
Dopamine
3-8 Years 80-378 ug/24 h
9-12 Years 51-474 µg/24 h
13-17 Years 51-645 µg/24 h
>17 Years 52-480 µg/24 h
Total Catecholamines
3-8 Years 9-51 µg/24 h
9-12 Years 9-71 µg/24 h
13-17 Years 13-90 µg/24 h
>17 Years 26-121 µg/24 h
Clinical Significance
Fractionated catecholamine measurement is useful in the diagnosis of pheochromocytoma and its differentiation from essential hypertension.
Performing Laboratory
| Quest Diagnostics Nichols Institute-Chantilly VA |
| 14225 Newbrook Drive |
| Chantilly, VA 20151-2228 |
