Prolactin, Total and Monomeric (PROTM)

Test Code
LAB4365


Quest Code
16122


CPT Codes
84146 (x2)

Includes
Prolactin, Total
Prolactin, Monomeric


Preferred Specimen
1 mL serum in plain red top tube


Patient Preparation
Fasting specimen is recommended but not required

Minimum Volume
0.4 mL


Instructions
Collect blood by venipuncture into plain tubes (without anticoagulant). Separate the serum from the cells.


Transport Container
Transport tube


Transport Temperature
Room temperature


Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 6 months


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate and gross hemolysis • Plasma


Methodology
Immunoassay (IA) • PEG Precipitation

Setup Schedule
Wednesday


Reference Range
Prolactin, Total
Females (>18 years)
  Non-pregnant3.0-30.0 ng/mL
  Pregnant10.0-209.0 ng/mL
  Post-menopausal2.0-20.0 ng/mL

Males (>18 years)2.0-18.0 ng/mL

Stages of Puberty (Tanner Stages)
 Female 
Observed
Male 
Observed
Stage I3.6-12.0 ng/mL≤10.0 ng/mL
Stage II-III2.6-18.0 ng/mL≤6.1 ng/mL
Stage IV-V3.2-20.0 ng/mL2.8-11.0 ng/mL

Prolactin, Monomeric
Adult Reference Ranges for Prolactin, Monomeric
Females3.2-25.2 ng/mL
Males3.4-14.8 ng/mL


Clinical Significance
For some patients the level of Prolactin measured by immunoassay may be inaccurate with respect to the level of monomeric, biologically active Prolactin. The Macroprolactin by PEG Precipitation test can help to identify if a patient sample has elevated Prolactin due to mostly inactive protein-bound Prolactin (Macroprolactin).


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano , CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.