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Histoplasma Antibody, Complement Fixation (HISTCF)
Test CodeLAB2289
Quest Code
938
Alias/See Also
HISTCF
CPT Codes
86317 (x2)
Includes
Yeast Phase Antibody and Mycelial Phase Antibody
Preferred Specimen
1 mL serum in gold top tube
Minimum Volume
0.5 mL
Instructions
For optimal results, collect serum specimen from fasting patients, and maintain aseptically
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly icteric
Methodology
Complement Fixation (CF)
Setup Schedule
Mon-Fri
Report Available
5 days
Reference Range
| Yeast Phase Ab | <1:8 titer |
| Mycelial Phase Ab | <1:8 titer |
Interpretive Criteria
| <1:8 | Antibody Not Detected |
| ≥1:8 | Antibody Detected |
Clinical Significance
This test is used for the diagnosis and prognosis of histoplasma infections. Titers ≥1:32 are highly suggestive of H. capsulatum infection. The CF test is more frequently positive with sera from chronic active pulmonary histoplasmosis than sera from primary active pulmonary disease.
Performing Laboratory
| Quest Diagnostics Nichols Institute-Chantilly VA |
| 14225 Newbrook Drive |
| Chantilly , VA 20151-2228 |
