Myelin Basic Protein (CMBP)

Test Code

LAB190

Quest Code

663

Alias/See Also

CMBP

CPT Codes
83873

Preferred Specimen

1.2 mL CSF

Minimum Volume

0.5 mL

Instructions

CSF must be clear. Do not centrifuge. CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Xanthochromia/RBCs in CSF

Methodology
Radioimmunoassay (RIA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

AM Monday-friday

Report Available

4 days

Limitations

The pesence of myelin basic protein in the spinal fluid is supportive evidence for the diagnosis of multiple sclerosis and other demyelinating diseases, although it is a non-specific finding and present in other causes of damage to CNS myelin.

Reference Range

≤4.0 mcg/L	Negative
4.1-6.0 mcg/L	Weakly positive
>6.0 mcg/L	Positive

Clinical Significance

The concentration of MBP is often increased in patients with demyelinating diseases such as multiple sclerosis and may be increased in patients with head injury, CNS trauma, tumor, stroke, and viral encephalitis.

Performing Laboratory

Quest Diagnostics Nichols Institute-Chantilly VA

14225 Newbrook Drive

Chantilly, VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.