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Topiramate (TOPAMX)
Test CodeLAB498
Quest Code
30965
Alias/See Also
TOPAMX
CPT Codes
80201
Preferred Specimen
1 mL serum collected in a red top tube (no gel) or no additive (royal blue-top) tube or 1 mL plasma collected in a lithium heparin (green-top) tube
Patient Preparation
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady state
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in: Sodium heparin lead-free (tan-top) tube or sodium heparin (green-top) tube
Instructions
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady state.
Transport Container
Plain red top (no gel)
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gel barrier/Serum Separator Tube (SST®)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Am Monday-saturday
Report Available
3 days
Reference Range
Therapeutic Range
| Dose (mg) | Peak (mcg/mL) | Trough (mcg/mL) |
| 100 | 6.5-9.2 | 4.5-6.6 |
| 200 | 12.0-16.0 | 8.0-12.0 |
| 400 | 20.0-30.0 | 14.0-20.0 |
Clinical Significance
Topiramate is an anticonvulsant used as an adjunctive treatment of partial-onset epilepsy. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.
Performing Laboratory
| Quest Diagnostics Nichols Institute-Chantilly VA |
| 14225 Newbrook Drive |
| Chantilly, VA 20151-2228 |
