Beta-2-Microglobulin, Serum (BETA2)

Test Code
LAB49

Quest Code
852

Alias/See Also
BETA2

CPT Codes
82232

Preferred Specimen
1 mL serum in gold top tube

Minimum Volume
0.5 mL

Other Acceptable Specimens
Plain red top tube

Instructions
Overnight fasting is preferred.

Transport Container


Serum Separator Tube or plastic screw-cap vial

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days

Methodology
Nephelometry

Setup Schedule
8am Mon, tues, wed, thurs, fri

Report Available
4 days

Reference Range
<18 Years Not established
Adults ≤2.51 mg/L


Clinical Significance
Beta-2-microglobulin normally passes through the glomerulus into the proximal tubule where much of it is reabsorbed. Serum levels are therefore an index of glomerular function. When impaired, serum levels rise in inverse ratio to glomerular filtration rate. Increased amounts of beta-2-microglobulin are excreted in several renal disorders, e.g., Balkan nephropathy, heavy metal poisoning and renal tubular disease due to therapeutic agents. Serial levels of beta-2-microglobulin in serum and urine are used to evaluate transplant viability and anticipate rejection. Following a successful graft, serum levels decline toward normal. Increasing serum levels provide an early sign of rejection. Elevated levels are also noted in lymphproliferative disorders, neoplasms (malignant and benign), inflammatory disease, and autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's disease.

Performing Laboratory
Quest Diagnostics - South Region




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.