| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Thyroid Cancer Monitoring (THYCAN)
Test CodeLAB4358
Quest Code
90814
CPT Codes
86800
Includes
If Thyroglobulin Antibody is negative, then Thyroglobulin is tested on the Beckman Coulter DxI (CPT code: 84432).
If Thyroglobulin Antibody is positive, then Thyroglobulin is tested by LC/MS/MS (CPT code: 84432).
If Thyroglobulin Antibody is positive, then Thyroglobulin is tested by LC/MS/MS (CPT code: 84432).
Preferred Specimen
3 mL serum
Minimum Volume
1.5 mL
Instructions
Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.
Transport Container
Preferred: Gold top; Acceptable: Plain red top
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 6 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Lipemia • Plasma • Icteric specimen
Methodology
Immunoassay • Liquid Chromatography/Tandem Mass Spectrometry
Setup Schedule
Mon-Fri
Reference Range
≤2 IU/mL
Clinical Significance
Thyroglobulin measurements are most useful in the postoperative monitoring of patients with papillary, follicular, and Hurthle cell carcinomas. However, approximately 20% of individuals develop autoantibodies to thyroglobulin. Since these antibodies interfere with immunoassay measurement of thyroglobulin, it is necessary to determine the presence or absence of antibodies before measuring thyroglobulin. This panel provides a sensitive method for determination of thyroglobulin autoantibodies, with subsequent measurement of thyroglobulin by either a sensitive immunoassay (Tg Ab negative samples) or LCMSMS (Tg Ab positive samples). The mass spectrometry assay has no interference from autoantibodies.
Performing Laboratory
| Quest Diagnostics Nichols Institute-Chantilly VA |
| 14225 Newbrook Drive |
| Chantilly, VA 20151-2228 |
