Tissue Transglutaminase Antibodies (IgG, IgA) (TTABGA)

Test Code

Quest Code

Alias/See Also

CPT Codes
83516 (x2)

Preferred Specimen
1 mL serum in gold top tube

Minimum Volume
0.5 mL

Other Acceptable Specimens
Plain red top tube

Transport Container
Transport tube

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic

Immunoassay (IA)

Setup Schedule
Noon cutoff in dept; 4pm setup; Report by 11pm Monday thru friday

Report Available
3 days

Reference Range
Tissue Transglutaminase Antibody, IgG
<6 U/mL No antibody detected
≥6 U/mL Antibody detected
Tissue Transglutaminase Antibody, IgA
<4 U/mL No antibody detected
≥4 U/mL Antibody detected

Clinical Significance
Tissue Transglutaminase Antibody, IgA, is useful in diagnosing gluten-sensitive enteropathies, such as Celiac Sprue Disease, and an associated skin condition, dermatitis herpetiformis. The IgG test is useful in patients who are IgA-deficient. The IgG test also provides support for gluten-sensitive enteropathies beyond the IgA test.

Performing Laboratory
Quest Diagnostics - South Region

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.