Thyroid Peroxidase and Thyroglobulin Antibodies (TPTGAB)

Test Code

Quest Code

CPT Codes
86376, 86800


Preferred Specimen
1 mL serum in gold top tube

Patient Preparation
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Other Acceptable Specimens
Plain red top tube

Transport Container
Transport tube

Transport Temperature
Room Temperature

Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolyzed or lipemic

Immunoassay (IA)

Reference Range
Thyroid Peroxidase Ab <9 IU/mL
Thyroglobulin Ab ≤1 IU/mL

Clinical Significance
Measurement of thyroglobulin antibodies and thyroid peroxidase antibodies is useful in the diagnosis and management of a variety of thyroid disorders including autoimmune thyroiditis, Hashimoto's Disease, Graves Disease and certain types of goiter.

Performing Laboratory
Quest Diagnostics - South Region

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.