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Herpesvirus 8 IgG Antibody, IFA
Test Code37959X
Preferred Specimen
Red Top
Minimum Volume
0.1 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Thurs; Report available: 1-7 days
Reference Range
<1:20 titer
Interpretive Criteria
Human herpesvirus-8 (HHV-8), also known as titer Kaposi's Sarcoma Herpesvirus (KSHV), is found in most cases of KS, including classic KS as well as AIDS-related KS. HHV-8 has also been detected in titer B-cell lymphomas in the abdominal cavity. IgG antibodies recognizing HHV-8 are found in >80% of titer KS patients and approximately 30% of titer HIV-seropositive individuals without KS, but less than 5% of healthy blood donors.
Interpretive Criteria
| <1:20 | Antibody Not Detected |
| ≥1:20 | Antibody Detected |
Clinical Significance
Human herpesvirus 8 (HHV-8) is associated with the development of all forms of Kaposi's sarcoma as well as with some other rare lymphoproliferative diseases, such as primary effusion lymphoma and multicentric Castleman's disease. Qualitative PCR is often used to aid in diagnosis of an HHV-8 infected individual. Quantitative PCR may be used to monitor the level of viremia in a patient, often in the context of therapy.
