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Porphyrins, Fractionated, Plasma
Test Code5519 (5519X)
Includes
Uroporphyrin, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Coproporphyrin, Protoporphyrin, Total Porphyrins
Preferred Specimen
!!!-LOOK ALIKE-SOUND ALIKE-!!!
SODIUM HEPARIN, Green Top
Tube will read "Sodium Heparin"
SODIUM HEPARIN, Green Top
Tube will read "Sodium Heparin"
Minimum Volume
0.6 mL
Other Acceptable Specimens
Frozen plasma collected in: EDTA (lavender-top) tube - protect from light • Serum collected in: Red-top tube (no gel) - protect from light
Instructions
PROTECT FROM LIGHT
Transport Temperature
Frozen
Specimen Stability
Room temperature: 8 hours
Refrigerated: 8 hours
Frozen: 90 days
Refrigerated: 8 hours
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received room temperature • Received refrigerated • Not protected from light • Serum Separator Tube (SST®)
Methodology
High Performance Liquid Chromatography (HPLC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Sun, Wed; Report available: 5-10 days
Reference Range
| Uroporphyrin | ≤0.2 mcg/L |
| Heptacarboxyporphyrin | ≤0.2 mcg/L |
| Hexacarboxyporphyrin | ≤0.3 mcg/L |
| Pentacarboxyporphyrin | ≤0.4 mcg/L |
| Coproporphyrin | ≤0.8 mcg/L |
| Protoporphyrin | 0.4-4.8 mcg/L |
| Total Porphyrins | 1.0-5.6 mcg/L |
Clinical Significance
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin fractionation of plasma is useful in diagnosing certain types of porphyrias and excluding porphyrias in patients with chronic renal failure suspected of having a porphyria.
