Aldosterone, Response to ACTH Stimulation, LC/MS/MS

Test Code

17832

Includes

Aldosterone, Baseline
Aldosterone, 60 minutes

Preferred Specimen

TWO Red Top Tubes

Minimum Volume

0.25 mL (each specimen)

Other Acceptable Specimens

Plasma collected in each of two separate: EDTA (lavender-top), sodium heparin (green-top) or lithium heparin (green-top) tubes

Instructions

Draw baseline specimen. Draw another specimen 60 minutes after stimulation.
Serum separator tubes (SST) are unacceptable. Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes.
Draw "upright" specimens at least 1/2 hour after patient sits up.

Note: Cortrosyn (cosyntropin) not supplied by the laboratory.
This test cannot be collected at a Patient Service Center.

Transport Container

Transport tube(s)

Transport Temperature

Frozen

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Moderate to gross hemolysis • Serum separator tube (SST)

Methodology
Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range

See Laboratory Report

Clinical Significance

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.