AALP Apolipoprotein C3

Test Code

37866

Preferred Specimen

Red Top

Patient Preparation
Patient should be fasting 10-12 hours

Minimum Volume

0.5 mL

Instructions

1. Collect and label sample according to standard protocols.
2. Gently invert tube 5 times immediately after draw. Do not shake.
3. Allow blood to clot for 30 minutes.
4. Centrifuge for 10 minutes.
5. Store serum at 2-8° C after collection and ship the same day.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 21 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Lipemia

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

This test is not available for New York patient testing.

Setup Schedule

Every other day

Reference Range

Male	11.34-40.54 nmol/L
Female	13.42-49.88 nmol/L

Clinical Significance

ApoC3 has been reported to be tightly associated with triglyceride metabolism and coronary artery disease (CAD) susceptibility. HDL ApoC3 is elevated in CAD patients and inversely correlated with cholesterol efflux capacity [1]. Genetic epidemiological studies found that loss-of-function mutations in the ApoC3 gene is associated with reduced CAD risk and total ApoC3 is associated with increased risk for cardiovascular events [2,3]

References
1. Luo M, et al. 2017;7(1):2312. doi:10.1038/s41598-017- 02601-7
2. Crosby J, et al. 2014;371(1):22-31. doi:10.1056/NEJMoa 1307095
3. Jorgensen A, et al. 2014;371(1):32-41. doi:10.1056/NEJMoa 1308027

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.